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Mouse Monoclonal anti-TGF-ß1 Antibody

Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0908
ID Mouse Monoclonal anti-TGF-ß1 Antibody
Antigen Description Transforming growth factor beta 1 (TGF-ß1) is a member of the transforming growth factor beta superfamily of cytokines. The TGF-ß1 precursor contains 390 amino acids with an N-terminal signal peptide of 29 amino acids required for secretion from a cell, a 249 amino acid pro-region (latency associated peptide or LAP), and a 112 amino acid C-terminal region that becomes the active TGF-ß1 upon activation.Both LAP and TGF-ß1 exist as homodimers in circulation, but the disulfide linked homodimers of LAP and TGF-ß1 remain non-covalently associated, forming the small latent TGF-ß complex (SLC, 100 kD). The large latent TGF-ß complex (LLC, 235-260 kD) contains a third component, the latent TGF-ß binding protein (LTBP), which is linked to LAP by a single disulfide bond. LTBP does not confer latency but is for efficient secretion of the complex to extracellular sites. Free active TGF-ß1 can be released (activated) by many factors, including enzymes and low or high pH.TGF-ß1 is nearly 100% conserved across mammalian species. It has diverse biological functions in multiple cellular processes such as regulating proliferation and differentiation of various cell types. TGF-ß1 is also an important immunoregulatory cytokine, which is involved in the maintenance of self-tolerance, Th17 differentiation, and T-cell homeostasis.
Size 100ug
Immunogen Human TGF-ß1
Clone #21C11
Antibody Isotype Mouse IgG2a, ¿
Species Reactivity Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application ELISA Capture
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.