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Mouse Monoclonal anti-Spectrin ß1 Antibody

Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0904
ID Mouse Monoclonal anti-Spectrin ß1 Antibody
Antigen Description Spectrin ß1 (SPTB1) is one of the several beta-spectrins that constitute the major components of the cytoskeletal network in erythrocyte plasma membrane. It binds another structural protein, band 4.1, to form a complex that anchors to the cytoplasmic face of the plasma membrane via Ankyrin, which in turn binds to protein band 3. Mutations in spectrin have been linked to hereditary defects in the erythrocyte, such as hereditary elliptocytosis. Recent studies show that caspase- and calpain-mediated cleavage of spectrin leads to the production of a series of fragments collectively called spectrin breakdown products (SBDPs). Multiple studies have shown that SBDPs may serve as a biomarker for traumatic brain injury (TBI)4.
Size 100ug
Immunogen Recombinant Spectrin ß1
Clone #N385/21
Antibody Isotype Mouse IgG2a
Host Species Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application WB
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.