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Mouse Monoclonal anti-Rat CD172a (SIRPa) Antibody


Item#:
xAP-0872
Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0872
ID Mouse Monoclonal anti-Rat CD172a (SIRPa) Antibody
Antigen Description Rat CD172a, also known as a signal-regulatory protein a (SIRPa), is a 75-110 kD transmembrane glycoprotein involved in the receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily primarily expressed on monocytes/macrophages, granulocytes, dendritic cells and neurons. CD172a serves as a substrate of activated receptor ttyrosine kinases (RTKs). The interaction of the CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion and phagocytosis. CD47 (IAP) is an extracellular ligand for CD172a.
Size 100ug
Immunogen Rat peritoneal macrophages
Clone #OX-41
Antibody Isotype Mouse IgG2a, ¿
Species Reactivity Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application FC IHC IP WB
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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