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Mouse Monoclonal anti-NALCN Antibody

Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0861
ID Mouse Monoclonal anti-NALCN Antibody
Antigen Description NALCN is a voltage independent and non-selective ion channel highly expressed in the central nervous system, and permeable to Na+, K+, and Ca2+. Knockout of mouse NALCN gene results in neonatal lethality within 24 hours of post birth due to defects in respiratory rhythm. In hippocampal neurons, the activation of NALCN is regulated by neuropeptides such as neurotensin and Substance P (SP). The binding of SP to its receptor, Substance P receptor (SPR), activates the Src family of tyrosine kinases (SFK) and promotes its binding to mUNC80, a scaffold protein that recruits SFK to NALCN.#NALCN is also expressed in pancreatic islet cells where its function is regulated by the acetylcholine and M3 muscarinic receptor (M3R).
Size 100ug
Immunogen Fusion protein corresponding to amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN
Clone #N185/7
Antibody Isotype Mouse IgG1
Host Species Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application WB
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.