Mouse Monoclonal anti-NALCN Antibody

Item#:

xAP-0861

Size	Price	Quantity
100.0 ug	$400.00

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Product Overview

Catalog Number	xAP-0861
ID	Mouse Monoclonal anti-NALCN Antibody
Antigen Description	NALCN is a voltage independent and non-selective ion channel highly expressed in the central nervous system, and permeable to Na+, K+, and Ca2+. Knockout of mouse NALCN gene results in neonatal lethality within 24 hours of post birth due to defects in respiratory rhythm. In hippocampal neurons, the activation of NALCN is regulated by neuropeptides such as neurotensin and Substance P (SP). The binding of SP to its receptor, Substance P receptor (SPR), activates the Src family of tyrosine kinases (SFK) and promotes its binding to mUNC80, a scaffold protein that recruits SFK to NALCN.#NALCN is also expressed in pancreatic islet cells where its function is regulated by the acetylcholine and M3 muscarinic receptor (M3R).
Size	100ug
Immunogen	Fusion protein corresponding to amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN
Clone	#N185/7
Antibody Isotype	Mouse IgG1
Host Species	Mouse
Preparation	The antibody was purified by affinity chromatography.
Formulation	The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application	WB
Storage & Handling	Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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