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Armenian Hamster Monoclonal anti-Mouse/Rat CD49e Antibody


Item#:
xAP-0852
Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0852
ID Armenian Hamster Monoclonal anti-Mouse/Rat CD49e Antibody
Antigen Description CD49e is a 135 kD protein, also known as a5 integrin or VLA-5 a chain. It is a member of the integrin family, expressed on thymocytes, pro-B cells, activated T cells, and mast cells. CD49e associates with CD29 (integrin ß1 chain) to form the fibronectin receptor (VLA-5). CD49e plays a critical role in both adhesion and T cell costimulation. The primary ligand for CD49e/CD29 (VLA-5) is fibronectin. The HMa5-1 antibody has been shown to partially block CD49e mediated interactions. It has also been observed that plate-bound HMa5-1 antibody enhances IgE mediated degranulation and that in vivo injection of HMa5-1 antibody, in combination with anti-CD49d and anti-CD61 antibodies, blocks passive cutaneous anaphylaxis.
Size 100ug
Immunogen Affinity-Purified mouse VLA-5 protein (a5ß1, CD49e/CD29)
Clone #HMa5-1
Antibody Isotype Armenian Hamster IgG
Species Reactivity Armenian Hamster
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application FC IP
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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