Armenian Hamster Monoclonal anti-Mouse TIGIT (Vstm3) Antibody

Item#:

xAP-0828

Size	Price	Quantity
100.0 ug	$400.00

Catalog Number	xAP-0828
ID	Armenian Hamster Monoclonal anti-Mouse TIGIT (Vstm3) Antibody
Antigen Description	T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as V-set and transmembrane domain-containing protein 3 (Vstm3), is a 26 kD, type I transmembrane protein and member of the CD28 family. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. Its binding partners include CD155 (PVR) and CD112 (PVRL2). TIGIT is a negative regulator of NK and T cell activation. Engagement of TIGIT by dendritic cells results in their differentiation into a tolerogenic phenotype, with an increased secretion of IL-10 and a diminished production of IL-12. Mice deficient for TIGIT are more susceptible to autoimmune disease.
Size	100ug
Immunogen	Mouse TIGIT Tetramers
Clone	#4D4/mTIGIT
Antibody Isotype	Armenian Hamster IgG
Host Species	Armenian Hamster
Preparation	The antibody was purified by affinity chromatography.
Formulation	The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application	FC
Storage & Handling	Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.