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Mouse Monoclonal anti-Mouse LAP (TGF-ß1) Antibody

Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0777
ID Mouse Monoclonal anti-Mouse LAP (TGF-ß1) Antibody
Antigen Description Transforming growth factor beta (TGF-ß) is a cytokine that has critical functions in immune response by regulating Treg and Th17 cells. TGF-ß is first synthesized as pro-TGF-ß and then it is cleaved by furin proprotein convertase in the Golgi apparatus to produce the dimeric propeptides called latency-associated peptide (LAP) that non-covalently associates with the dimeric mature TGF-ß to prevent its activity. This complex can further associate with latent-TGF-ß-binding protein (LTBP) to produce a large latent form for deposition onto the extracellular matrix. The latent-TGF-ß can be expressed on the membrane of activated Treg cells, immature dendritic cells, megakaryocytes, and platelets.
Size 100ug
Immunogen Mouse Tgfb1-transduced P3U1 cells
Clone #TW7-20B9
Antibody Isotype Mouse IgG1
Host Species Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application FC IP WB Neut
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.