Rat Monoclonal anti-Mouse DCIR4 (Clec4a1) Antibody

Item#:

xAP-0716

Size	Price	Quantity
100.0 ug	$320.00

please find our citations on google scholar

Product Overview

Catalog Number	xAP-0716
ID	Rat Monoclonal anti-Mouse DCIR4 (Clec4a1) Antibody
Antigen Description	Clec4a1 or dendritic cell inhibitory receptor 4 (DCIR4) is a C-type lectin receptor (CLR) which belongs to DC immunoreceptor (DCIR) family. Inhibitory members of DCIR family are type II membrane glycoprotein consisting of a carbohydrate recognition domain (CDR) on their COOH terminus and immunoreceptor tyrosin-based inhibitory motifs (ITIM) on their intracellular domain. Studies indicate that inhibitory DCIRs play an anti-inflammatory role and that immunopathology related to rheumatoid arthritis and TB infection is driven by their loss. Inhibitory DCIR are found on DCs, B cells, monocytes, macrophages, and neutrophils, but not T or NK cells and relay signal through Src homology region 2 domain-containing phosphatase (SHP). DCIR4, yet to be confirmed to have inhibitory role, is exclusive to non-granulocytic myeloid cells and its expression level can be used to differentiate between patrolling and inflammatory monocytes.
Size	100ug
Immunogen	DCIR4 reporter cells
Clone	#MH7E7
Antibody Isotype	Rat IgG1
Host Species	Rat
Preparation	The antibody was purified by affinity chromatography.
Formulation	The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application	FC
Storage & Handling	Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

ANGIO-PROTEOMIE, ALL RIGHTS RESERVED