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Rat Monoclonal anti-Mouse CD8a Antibody

Size Price Quantity
100.0 ug $400.00
Catalog Number xAP-0703
ID Rat Monoclonal anti-Mouse CD8a Antibody
Antigen Description CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked a and ß chains that form the a(CD8a)/ß(CD8b) heterodimer and a/a homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 a/ß heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR a/ß T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 a/a homodimer is expressed on a subset of ¿/d TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.
Size 100ug
Immunogen Recombinant mouse CD8a
Clone #S18018A
Antibody Isotype Rat IgG1
Host Species Rat
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application IHC-F
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.