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Armenian Hamster Monoclonal anti-Mouse CD49b Antibody


Item#:
xAP-0668
Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0668
ID Armenian Hamster Monoclonal anti-Mouse CD49b Antibody
Antigen Description CD49b is a 150 kD glycoprotein, also known as a2 integrin, VLA-2 a chain, Integrin a2 chain, and HMa2. It is a member of the integrin family, expressed on NK cells, a subset of splenic CD4+ T cells, NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, epithelial cells, and platelets. By associating with CD29 (integrin ß1 subunit), CD49b forms the VLA-2 (integrin a2ß1 ) complex. It plays a critical role in both adhesion and lymphocyte activation. The primary ligands for CD49b are collagen, laminin, and fibronectin. The HMa2 antibody has been shown to be useful for partially blocking CD49b mediated interactions with collagen. Additionally, this antibody blocks staining of splenic NK cells by the monoclonal antibody DX5.
Size 100ug
Immunogen Mouse colon carcinoma cell line Colon26
Clone #HMa2
Antibody Isotype Armenian Hamster IgG
Species Reactivity Armenian Hamster
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application FC IHC-F IP Block
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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