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Rat Monoclonal anti-Mouse CD218a (IL-18Ra) Antibody


Item#:
xAP-0581
Size Price Quantity
100.0 ug $400.00
Catalog Number xAP-0581
ID Rat Monoclonal anti-Mouse CD218a (IL-18Ra) Antibody
Antigen Description The IL-18 receptor (IL-18R) complex is composed of two known chains, IL-18 receptor a (IL-18Ra) and IL-18 receptor ß (IL-18Rß). IL-18Ra (IL-1R5) is an IL-1 receptor super family member. It was originally described as IL-1 receptor-related protein (IL-1Rrp) because of its homology with the IL-1/Toll receptor family. IL-18Ra is the extracellular binding domain of the IL-18 receptor complex. It is expressed on the majority of peripheral CD4+ T cells, Th1 cells, and reciprocally repressed during Th2 development. The expression of IL-18Ra is induced by an IL-12/Stat4 pathway and inhibited by IL-4/Stat6 pathway. Binding of IL-18Ra together with IL-18ß to proinflammatory cytokine IL-18 plays an important role in innate and autoimmune responses.
Size 100ug
Immunogen Recombinant mouse CD218a
Clone #A17071D
Antibody Isotype Rat IgG2b
Host Species Rat
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application FC
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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