Rat Monoclonal anti-Mouse CD218a (IL-18Ra) Antibody

Item#:

xAP-0581

Size	Price	Quantity
100.0 ug	$400.00

Catalog Number	xAP-0581
ID	Rat Monoclonal anti-Mouse CD218a (IL-18Ra) Antibody
Antigen Description	The IL-18 receptor (IL-18R) complex is composed of two known chains, IL-18 receptor a (IL-18Ra) and IL-18 receptor ß (IL-18Rß). IL-18Ra (IL-1R5) is an IL-1 receptor super family member. It was originally described as IL-1 receptor-related protein (IL-1Rrp) because of its homology with the IL-1/Toll receptor family. IL-18Ra is the extracellular binding domain of the IL-18 receptor complex. It is expressed on the majority of peripheral CD4+ T cells, Th1 cells, and reciprocally repressed during Th2 development. The expression of IL-18Ra is induced by an IL-12/Stat4 pathway and inhibited by IL-4/Stat6 pathway. Binding of IL-18Ra together with IL-18ß to proinflammatory cytokine IL-18 plays an important role in innate and autoimmune responses.
Size	100ug
Immunogen	Recombinant mouse CD218a
Clone	#A17071D
Antibody Isotype	Rat IgG2b
Host Species	Rat
Preparation	The antibody was purified by affinity chromatography.
Formulation	The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application	FC
Storage & Handling	Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.