Armenian Hamster Monoclonal anti-Mouse CD178 (FasL) Antibody

Item#:

xAP-0555

Size	Price	Quantity
100.0 ug	$420.00

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Product Overview

Catalog Number	xAP-0555
ID	Armenian Hamster Monoclonal anti-Mouse CD178 (FasL) Antibody
Antigen Description	CD178 is a 40 kD member of the TNF/NGF superfamily also known as Fas ligand, FasL, Apo-1 ligand, and CD95 ligand. Cell surface CD178 is expressed on activated T cells and in testis and eye. CD178 is upregulated in activated T cells upon TCR re-engagement and has been shown to induce autocrine and paracrine T cell death. CD178 expression in the eye and testis has been shown to participate in immune privilege at these sites. CD178 can be cleaved from the surface by metalloproteases, and soluble CD178 may block the activities of membrane-bound CD178. CD178 binds to CD95 (Fas) to induce apoptotic cell death implicated in the maintenance of peripheral tolerance. CD178/CD95 interactions have also been implicated in the proliferation of CD8+ cells and neutrophil extravasation, chemotaxis, and survival. The MFL3 antibody recognizes CD178 in a wide array of mouse strains and has been reported to block CD178/CD95 induced apoptosis.
Size	100ug
Immunogen	B6 mouse FasL cDNA-transfected baby hamster kidney (B6 FasL/BHK) cells
Clone	#MFL3
Antibody Isotype	Armenian Hamster IgG
Host Species	Armenian Hamster
Preparation	The antibody was purified by affinity chromatography.
Formulation	The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application	FC ICC -
Storage & Handling	Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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