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Rat Monoclonal anti-Mouse CD123 Antibody

Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0522
ID Rat Monoclonal anti-Mouse CD123 Antibody
Antigen Description CD123 is a 70 kD a chain subunit of the IL-3 receptor (IL-3R a). It is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL-3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either the common ß chain (CDw131) or the IL-3R ß chain (AIC2A) to form high-affinity heterodimeric IL-3 receptors. CDw131 can complex with the a subunits of the mouse IL-3R, IL-5R and GM-CSFR to form high-affinity receptors, while the IL-3 R ß subunit is specific for IL-3 but binds with low affinity. IL-3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. The 5B11 antibody does not block binding of IL-3 to the high affinity IL-3 receptor.
Size 100ug
Immunogen CTLL cells transfected with the mouse IL-3Ra chain
Clone #5B11
Antibody Isotype Rat IgG2a
Host Species Rat
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application FC
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.