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Mouse Monoclonal anti-MAP3K12 Antibody

Size Price Quantity
100.0 ug $400.00
Catalog Number xAP-0488
ID Mouse Monoclonal anti-MAP3K12 Antibody
Antigen Description Mitogen-activated protein kinase kinase kinase 12 (MAP3K12), also known as dual leucine zipper kinase (DLK), is a serine/threonine-protein kinase and part of the non-canonical MAPK signaling pathway. Primarily expressed in neurons at the synaptic terminals, MAP3K12 is a critical regulator of signaling cascades affecting neuronal migration and axon development as well as responding to peripheral nerve injury including transcriptional repression, axon regeneration, and neuronal apoptosis through its activation of transcription factors STAT3 and c-Jun. Its neuroprotective role in responding to injury makes MAP3K12 a promising therapeutic target in the study of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and optic neuropathy. Emerging evidence suggests a role for MAP3K12 in the proliferation and mass regulation of pancreatic beta cells via activation of c-Jun N-terminal kinase (JNK) signaling pathway and may be a target of interest in the study of the pathogenesis of insulin resistance.
Size 100ug
Immunogen Fusion protein corresponding to amino acids 727-888 (C-terminus) of mouse MAP3K12
Clone #N377/20
Antibody Isotype Mouse IgG1
Host Species Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application WB
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.