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Mouse Monoclonal anti-Iduna (RNF146) Antibody

Size Price Quantity
100.0 ug $400.00
Catalog Number xAP-0484
ID Mouse Monoclonal anti-Iduna (RNF146) Antibody
Antigen Description Ring finger protein 146 (RNF146), also known as Iduna, is a poly-ADP-ribose (PAR)-dependent E3 ubiquitin-protein ligase that promotes the degradation of PARsylated proteins. The ability of RNF146 to bind to PAR and thus inhibit PAR dependent cell death, or parthanatos, contributes to its role in DNA repair and cell survival and overall neuroprotective qualities. RNF146 has been identified as an NMDA receptor-induced survival gene that protects against NMDA receptor mediated excitotoxicity and ischemia-induced neuronal injury. RNF146 is a positive regulator of the Wnt/ ß-catenin signaling pathway through the ubiquitylation of AXIN following its degradation by tankyrase and has been implicated in embryonic and postnatal osteoblast development, bone remodeling, and energy metabolism via coordination of ß-catenin signaling and Hippo pathways within osteoblasts.
Size 100ug
Immunogen Full-length mouse Iduna (RNF146) protein
Clone #N201/35
Antibody Isotype Mouse IgG1
Host Species Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application WB
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.