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Mouse Monoclonal anti-Human Lymphotoxin beta receptor (LT-ßR) Antibody

Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0445
ID Mouse Monoclonal anti-Human Lymphotoxin beta receptor (LT-ßR) Antibody
Antigen Description LT-ßR, also known as lymphotoxin beta receptor and tumor necrosis factor receptor superfamily member 3 is a 47 kD transmembrane protein containing 3 TNF receptor domains. The LT-ßR is a receptor for the heterotrimeric lymphotoxin complex (composed of LTa and LTß as well as LIGHT). LT-ßR is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LT-ßR is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LT-ßR interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LT-ßR has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs. The 31G4D8 antibody has been shown to be useful for flow cytometry, Western blot, immunoprepicitation and and ELISA (detection antibody). In addition, the 31G4D8 antibody is an agonistic antibody for the LT-ßR capable of inducing apoptosis (with IFN-¿ treatment).
Size 100ug
Immunogen Human LT-ßR Fc protein
Clone #31G4D8
Antibody Isotype Mouse IgG2b
Host Species Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application FC WB IP
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.