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Mouse Recombinant anti-Human LAP Recombinant Antibody

Size Price Quantity
100.0 ug $400.00
Catalog Number xAP-0443
ID Mouse Recombinant anti-Human LAP Recombinant Antibody
Antigen Description TGF-ß1 (transforming growth factor ß1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many types of cells. Platelets express high level of TGF-ß. TGF-ß is synthesized as a large protein precursor and then secreted as a complex of TGF-ß and LAP (latency-associated peptide), in which LAP noncovalently associates with the dimeric mature TGF-ß to prevent its activity. TGF-ß requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-ß binds to the integrins avß1, avß6, avß8, and a8ß1 through RGD domain. TGF-ß plays important roles in control proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-ß is believed to be important in the regulation of the development of Treg, Th17, and Th9 cells. A recent study has shown that LAP is an activated Treg surface marker.
Size 100ug
Immunogen Recombinant human LAP
Clone #QA20A25
Antibody Isotype Mouse IgG1
Host Species Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application FC
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.