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Mouse Monoclonal anti-Human IFN-a2 Antibody

Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0390
ID Mouse Monoclonal anti-Human IFN-a2 Antibody
Antigen Description Interferons are divided into type I, II, and III. Type I IFNs (IFN-a and IFN-ß) are most abundant in number, distribution, and expression. Also, they are highly conserved among mammals in both structure and function. IFN-a2 has been used in the treatment of cancer such as bladder cancer, hepatocellular carcinoma, and leukemia. IFN-a2 augments the suppressed immune functions in patients with head and neck squamous cell carcinoma (HNSCC). IFN-a2 initiated T and NK cell mediated cytotoxicity of tumor cells through IFN¿ dependent and independent mechanisms. IFN-a2 enhances suppressed T cell cytotoxicity by stimulation of the perforin-granzyme B system (IFN¿ dependent). Also, IFN-a2 induces the expression of perforin-granzyme B in NK cells (NK mediated cytotoxicity, IFN¿ independent). In a preliminary study, IFN-a2 appears to be an effective immunostimulator and impacts the clinical outcome in tongue squamous cell carcinoma patients. IFN-a had been used in the treatment of chronic hepatitis C (CHC); nevertheless, IFN-a is relatively unstable and requires frequent parenteral administration. Pegylation of IFN-a, polyethylene glycol (PEG)-IFN-a, reduces in vitro activity but increase the stability and plasma half-life of IFN-a; therefore, PEG-IFN-a has replaced IFN-a in CHC treatment.
Size 100ug
Immunogen Recombinant protein
Clone #M4509E12
Antibody Isotype Mouse IgG1, ¿
Species Reactivity Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application ELISA Capture
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.