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Mouse Monoclonal anti-Human CD49d Antibody


Item#:
xAP-0292
Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0292
ID Mouse Monoclonal anti-Human CD49d Antibody
Antigen Description CD49d is a 150 kD a integrin chain known as a4 integrin or VLA-4 a chain. It forms a heterodimer with either integrin ß1 (a4ß1, VLA-4) or ß7 (a4ß7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. a4ß7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.
Size 100ug
Immunogen Recombinant human CD49d
Clone #9F10
Antibody Isotype Mouse IgG1, ¿
Species Reactivity Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application FC IHC-F Costim
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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