Mouse Monoclonal anti-Human CD49d Antibody

Item#:

xAP-0292

Size	Price	Quantity
100.0 ug	$400.00

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Product Overview

Catalog Number	xAP-0292
ID	Mouse Monoclonal anti-Human CD49d Antibody
Antigen Description	CD49d is a 150 kD a integrin chain known as a4 integrin or VLA-4 a chain. It forms a heterodimer with either integrin ß1 (a4ß1, VLA-4) or ß7 (a4ß7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. a4ß7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.
Size	100ug
Immunogen	Recombinant human CD49d
Clone	#9F10
Antibody Isotype	Mouse IgG1
Host Species	Mouse
Preparation	The antibody was purified by affinity chromatography.
Formulation	The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application	FC IHC-F Costim
Storage & Handling	Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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