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Mouse Monoclonal anti-Human CD172a/b (SIRPa/ß) Antibody


Item#:
xAP-0140
Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0140
ID Mouse Monoclonal anti-Human CD172a/b (SIRPa/ß) Antibody
Antigen Description CD172a, also known as signal-regulatory protein a (SIRPa), src homology 2 domain-containing phosphatase substrate-1 (SHPS1), PTPNS1, BIT, MFR, and P84, is a 75-110 kD transmembrane glycoprotein involved in receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily and is primarily expressed on monocytes/macrophages, granulocytes, dendritic cells, and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs). The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion, and phagocytosis. CD47 (IAP) is the extracellular ligand for CD172a. SIRPa was recently demonstrated to be a specifc marker for cardiomyocytes derived from human pluripotent stem cells2.
Size 100ug
Immunogen NIH-3T3/hu-SIRPa cell line
Clone #SE5A5
Antibody Isotype Mouse IgG1, ¿
Species Reactivity Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application FC
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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