Mouse Monoclonal anti-Human CD140a (PDGFRa) Antibody

Item#:

xAP-0105

Size	Price	Quantity
100.0 ug	$320.00

please find our citations on google scholar

Product Overview

Catalog Number	xAP-0105
ID	Mouse Monoclonal anti-Human CD140a (PDGFRa) Antibody
Antigen Description	The 16A1 monoclonal antibody recognizes human CD140a also known as the platelet-derived growth factor receptor, alpha polypeptide, PDGFR2, and PDGFRa. CD140a is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. The identity of the growth factor bound to the receptor determines whether the functional receptor is a homodimer or heterodimer composed of both PDGFR-a and -ß. CD140a contains three immunoglobulin-like domains and a tyrosine kinase domain with a predicted molecular weight of approximately 123 kD. CD140a is widely expressed on a variety of mesenchymal-derived cells and has been implicated in the development of some tumors including basal cell carcinoma and gastric stromal cell tumors. Binding of A-chain containing PDGF molecules as well as protease-activated PDGF-C molecules can stimulate cell proliferation. CD140a has been shown to interact with a number of proteins including CRK, Grb2, Grb14, SHP2, and others as integrin ß3, caveolin-1, and nexin sorting molecules. The PDGFRa is heavily phosphorylated on numerous tyrosine residues through both autophosphorylation and ligand-dependent processes. The 16A1 antibody has been shown to be useful for flow cytometric detection of CD140a.
Size	100ug
Immunogen	NIH 3T3 cells transfected with human PDGFRalpha
Clone	#16A1
Antibody Isotype	Mouse IgG1
Host Species	Mouse
Preparation	The antibody was purified by affinity chromatography.
Formulation	The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application	FC ICC -
Storage & Handling	Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

ANGIO-PROTEOMIE, ALL RIGHTS RESERVED