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Mouse Monoclonal anti-Human CD103 (Integrin aE) Antibody


Item#:
xAP-0049
Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0049
ID Mouse Monoclonal anti-Human CD103 (Integrin aE) Antibody
Antigen Description CD103 is a type I transmembrane glycoprotein also known as aE integrin, integrin aIEL chain, and human mucosal lymphocyte antigen 1. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. Treg cells express high level of CD103. Hairy cell leukemia has also been shown to express CD103. The expression of CD103 on lymphocytes can be induced upon activation and TGF-ß stimulation. In association with integrin ß7, CD103 is expressed as an aE/ß7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.
Size 100ug
Immunogen HTLV-1 induced human T cell line MAPS16
Clone #Ber-ACT8
Antibody Isotype Mouse IgG1, ¿
Species Reactivity Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application FC WB IP IHC-F
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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