Mouse Monoclonal anti-HCN4 Antibody

Item#:

xAP-0033

Size	Price	Quantity
100.0 ug	$400.00

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Product Overview

Catalog Number	xAP-0033
ID	Mouse Monoclonal anti-HCN4 Antibody
Antigen Description	Hyperpolarization activated cyclic nucleotide gated ion channel 4 (HCN4) is a subunit of a total 4 HCN protein family that carries inward current with the feature knows as If in the heart and Ih in the brain. These currents have been indicated in a wide array of physiological activities, including pacemaker activity of neurons, and cardiomyocytes, control of resting membrane potential, neuronal plasticity, dendrite formation and response to sour taste. Although widely expressed in the central nervous system, HCN4 is enriched in regions regulating mood and anxiety including thalamus, amygdala, midbrain dopamine system, and indirectly prefrontal cortex. SNP genotyping indicates the association of HCN4 with mood anxiety disorders. In cardiomycates, HCN4 is required for pacemaker potential generation. Mice lacking HCN4 globally or in cadiomyocytes are embryonic lethal.
Size	100ug
Immunogen	Fusion protein corresponding to amino acids 1021-1110 (cytoplasmic C-terminus) of human HCN4
Clone	#N114/10
Antibody Isotype	Mouse IgG1
Host Species	Mouse
Preparation	The antibody was purified by affinity chromatography.
Formulation	The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application	WB IHC-P
Storage & Handling	Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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