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Mouse Monoclonal anti-HCN4 Antibody

Size Price Quantity
100.0 ug $400.00
Catalog Number xAP-0033
ID Mouse Monoclonal anti-HCN4 Antibody
Antigen Description Hyperpolarization activated cyclic nucleotide gated ion channel 4 (HCN4) is a subunit of a total 4 HCN protein family that carries inward current with the feature knows as If in the heart and Ih in the brain. These currents have been indicated in a wide array of physiological activities, including pacemaker activity of neurons, and cardiomyocytes, control of resting membrane potential, neuronal plasticity, dendrite formation and response to sour taste.  Although widely expressed in the central nervous system, HCN4 is enriched in regions regulating mood and anxiety including thalamus, amygdala, midbrain dopamine system, and indirectly prefrontal cortex. SNP genotyping indicates the association of HCN4 with mood anxiety disorders. In cardiomycates, HCN4 is required for pacemaker potential generation. Mice lacking HCN4 globally or in cadiomyocytes are embryonic lethal.
Size 100ug
Immunogen Fusion protein corresponding to amino acids 1021-1110 (cytoplasmic C-terminus) of human HCN4
Clone #N114/10
Antibody Isotype Mouse IgG1
Host Species Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application WB IHC-P
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.