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Mouse Monoclonal anti-CD105 (Endoglin) Antibody

Size Price Quantity
100.0 ug $400.00
Catalog Number xAP-0017
ID Mouse Monoclonal anti-CD105 (Endoglin) Antibody
Antigen Description CD105 (Endoglin) is expressed by endothelial cells, pro-fibrogenic cells and hepatic stellate cells; it plays important roles in endothelial proliferation and cardiovascular development. Mutations in the ENG gene lead to Hereditary Hemorrhagic Telangiectasia, a disorder characterized by arteriovenous malformations. An extracellular domain of the full-length membrane endoglin, soluble endoglin, is a proposed biomarker of cardiovascular disease progression, cardiovascular disease treatment and endothelial dysfunction. Endoglin is also expressed in the syncytiotrophoblast throughout pregnancy, but transiently upregulated in the extravillous trophoblast of anchoring villi. Furthermore, endoglin is overexpressed in the tumor-associated vascular endothelium, where it modulates angiogenesis.
Size 100ug
Immunogen Full length recombinant protein of human Endoglin/CD105 expressed in HEK293T.
Clone #O99E5
Antibody Isotype Mouse IgG1
Host Species Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application WB
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.