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Mouse Monoclonal anti-Cavß4 Antibody

Size Price Quantity
100.0 ug $320.00
Catalog Number xAP-0014
ID Mouse Monoclonal anti-Cavß4 Antibody
Antigen Description Voltage-dependent L-type calcium channel subunit beta-4 (Cavÿ4) is a member of the membrane-associated guanylate kinase (GK) protein family and a cytoplasmic subunit of voltage-gated calcium channels. Expressed predominantly in the cerebellum and kidney, it is responsible for calcium entry into nerve termini and subsequent neurotransmitter release via its association with membrane-trafficking protein synaptotagmin 1 (Syt 1). It regulates synaptic transmission, increases the readily releasable pool of synaptic vesicles, and plays a role in synaptic vesicle plasticity and maturation through its association with Cavÿ1, RIM1, and actin filaments (F-actin). Cavÿ4 has been linked to psychiatric and anxiety disorders including major depressive disorder (MDD) and schizophrenia and is a potential therapeutic target in their study and treatment.
Size 100ug
Immunogen Synthetic peptide corresponding to amino acids 458-474 of rat Cavß4
Clone #N10/7
Antibody Isotype Mouse IgG1
Host Species Mouse
Preparation The antibody was purified by affinity chromatography.
Formulation The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application WB
Storage & Handling Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.