Mouse Monoclonal anti-Arl13b Antibody

Item#:

xAP-0007

Size	Price	Quantity
100.0 ug	$420.00

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Product Overview

Catalog Number	xAP-0007
ID	Mouse Monoclonal anti-Arl13b Antibody
Antigen Description	The ADP-ribosylation factor (Arf)-like small GTPase Arl13b is a small GTPase mainly found in primary cilia of neuroeptithelial cells, radial glial cells and fibroblast. The Arl13b null mice display multiple structural defects in the neural tube, limbs, and eyes. Loss of Arl13b function is associated with impaired sonic hedgehog signaling, disrupted cilia polarity and scaffold in radial progenitor cells. Three mutations in human Arl13b gene have been identified in Joubert Syndrom (JS) patients, two of which are located in the GTP-binding sensitive switch region, known as switch 2 region. Consistent with the mutant phenotype in the mouse null allele, Joubert syndrome patients are characterized with neural, ocular and renal defects, and mental retardation. Multiple studies have suggested that the role of Arl13b in ciliogenesis is mediated by the sonic hedgehog signaling.#Recently, Arl13b was also shown to mediate endocytic trafficking of CD1a, an MHC-class 1 like antigen presenting molecule which presents lipids rather proteins. Loss of Arl13b causes the clustering of early endosomes and accumulation of endocytic cargos. In this process, Arl13 colocalizes with 2 other endocytic markers, Arf2 and Rab22a, and may interact with actin cytoskeleton.
Size	100ug
Immunogen	Fusion protein corresponding to amino acids 208-427 (C-terminus) of mouse Arl13b.
Clone	#N295B/66
Antibody Isotype	Mouse IgG2a
Host Species	Mouse
Preparation	The antibody was purified by affinity chromatography.
Formulation	The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS).
Application	WB IHC-P
Storage & Handling	Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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