Mouse Monoclonal Antibody to ERCC1

Item#:

sAP-1165

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-1165
Product Name	Mouse Monoclonal Antibody to ERCC1
Target Molecle	ERCC1
Aliases	UV20; COFS4; RAD10
Species	Human;
MW	32.6kDa
Enterez GeneID	2067
General Information	The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.;
Immunogen	Purified recombinant fragment of human ERCC1 (AA
Clone	MM1A5A2;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1.J Clin Invest. 2009 Aug;119(8)