Mouse Monoclonal Antibody to CASP3

Item#:

sAP-1101

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-1101
Product Name	Mouse Monoclonal Antibody to CASP3
Target Molecle	CASP3
Aliases	CPP32; SCA-1; CPP32B
Species	Human;
MW	31.6kDa
Enterez GeneID	836
General Information	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Immunogen	Purified recombinant fragment of human CASP3 (AA
Clone	MM3D4D7;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	J Gastroenterol. 2013 Nov;48(11)