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Mouse Monoclonal Antibody to WAS
Item#:
sAP-1065
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-1065
Product Name Mouse Monoclonal Antibody to WAS
Target Molecle WAS
Aliases THC; IMD2; SCNX; THC1; WASP
Species Human;
MW 53kDa
Enterez GeneID 7454
General Information The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
Immunogen Purified recombinant fragment of human WAS (AA
Clone MM7B10E4;
Isotype Mouse IgG2a
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Blood. 2012 Aug 23;120(8)
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