Mouse Monoclonal Antibody to RAP1GAP

Item#:

sAP-1053

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-1053
Product Name	Mouse Monoclonal Antibody to RAP1GAP
Target Molecle	RAP1GAP
Aliases	RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII
Species	Human;
MW	73.4kDa
Enterez GeneID	5909
General Information	This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Immunogen	Purified recombinant fragment of human RAP1GAP (AA
Clone	MM2G7B6;
Isotype	Mouse IgG2b
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Liver Int. 2012 Oct;32(9)