Mouse Monoclonal Antibody to RBL2

Item#:

sAP-1044

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-1044
Product Name	Mouse Monoclonal Antibody to RBL2
Target Molecle	RBL2
Aliases	Rb2; P130
Species	Human;
MW	128.4kDa
Enterez GeneID	5934
General Information	RBL2 is a Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Immunogen	Purified recombinant fragment of human RBL2 (AA
Clone	MM2C8A8;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Oncogene. 2007 Feb 1;26(5)