Mouse Monoclonal Antibody to CD22

Item#:

sAP-0843

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0843
Product Name	Mouse Monoclonal Antibody to CD22
Target Molecle	CD22
Aliases	SIGLEC2; SIGLEC-2
Species	Human;
MW	95.3kDa
Enterez GeneID	933
General Information	CD22 may be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules ;
Immunogen	Purified recombinant fragment of human CD22 (AA
Clone	MM1A3A11;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. J Cancer Res Clin Oncol. 2012 Aug;138(8)