Mouse Monoclonal Antibody to NPC1

Item#:

sAP-0832

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0832
Product Name	Mouse Monoclonal Antibody to NPC1
Target Molecle	NPC1
Aliases	NPC
Species	Human;
MW	142.2kDa
Enterez GeneID	4864
General Information	This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments. ;
Immunogen	Purified recombinant fragment of human NPC1 (AA
Clone	MM8D10B6;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Am J Pathol. 2012 Aug;181(2)