Mouse Monoclonal Antibody to FLT3

Item#:

sAP-0802

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0802
Product Name	Mouse Monoclonal Antibody to FLT3
Target Molecle	FLT3
Aliases	FLK2; STK1; CD135; FLK-2
Species	Human;
MW	130kDa
Enterez GeneID	2322
General Information	This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. ;
Immunogen	Purified recombinant fragment of human FLT3 (AA
Clone	MM7B7C3;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Cancer Res. 2013 Jan 15;73(2)