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Mouse Monoclonal Antibody to E2F1
Item#:
sAP-0734
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0734
Product Name Mouse Monoclonal Antibody to E2F1
Target Molecle E2F1
Aliases RBP3; E2F-1; RBAP1; RBBP3
Species Human; Mouse
MW 46.9kDa
Enterez GeneID 1869
General Information The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Immunogen Purified recombinant fragment of human E2F1 (AA
Clone MM8G9;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1.Cell. 2011 Oct 28;147(3)
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