Mouse Monoclonal Antibody to PPM1A

Item#:

sAP-0726

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0726
Product Name	Mouse Monoclonal Antibody to PPM1A
Target Molecle	PPM1A
Aliases	PP2CA; PP2Calpha; PP2C-ALPHA
Species	Human; Monkey
MW	42.4kDa
Enterez GeneID	5494
General Information	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Immunogen	Purified recombinant fragment of human PPM1A (AA
Clone	MM7F12;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1.Br J Cancer. 2010 Feb 16;102(4)