Mouse Monoclonal Antibody to RAF1

Item#:

sAP-0680

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0680
Product Name	Mouse Monoclonal Antibody to RAF1
Target Molecle	RAF1
Aliases	NS5; CRAF; Raf-1; c-Raf
Species	Human
MW	73kDa
Enterez GeneID	5894
General Information	This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Immunogen	Purified recombinant fragment of human RAF1 expressed in E. Coli. ;
Clone	MM4G4;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	Cancer Res. 2007 Jun 1;67(11)