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Mouse Monoclonal Antibody to FAS
Item#:
sAP-0676
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0676
Product Name Mouse Monoclonal Antibody to FAS
Target Molecle FAS
Aliases APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
Species human
MW 37.7kDa
Enterez GeneID 355
General Information The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Immunogen Purified recombinant fragment of human FAS expressed in E. Coli. ;
Clone MM4F8H6;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Am J Hum Genet. 2009 Nov;85(5)
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