Mouse Monoclonal Antibody to ROCK1

Item#:

sAP-0654

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0654
Product Name	Mouse Monoclonal Antibody to ROCK1
Target Molecle	ROCK1
Aliases	ROCK-I; PRO0435; MGC43611; P160ROCK; MGC131603
Species	Human
MW	158kDa
Enterez GeneID	6093
General Information	This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Immunogen	Purified recombinant fragment of human ROCK1 expressed in E. Coli. ;
Clone	MM1H4;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. BMC Cancer. 2010 Feb 24;10