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Mouse Monoclonal Antibody to PSMB8
Item#:
sAP-0605
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0605
Product Name Mouse Monoclonal Antibody to PSMB8
Target Molecle PSMB8
Aliases JMP; LMP7; D6S216; PSMB5i; RING10; D6S216E; MGC1491
Species Human; Rat
MW 30kDa
Enterez GeneID 5696
General Information The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.
Immunogen Purified recombinant fragment of human PSMB8 expressed in E. Coli. ;
Clone MM1A5;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. J Biol Chem. 2010 Mar 12;285(11)
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