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Mouse Monoclonal Antibody to p63a
Item#:
sAP-0528
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0528
Product Name Mouse Monoclonal Antibody to p63a
Target Molecle p63a
Aliases P51B; KET; p63a
Species Human; Mouse; Rat; Monkey
MW 51kDa
Enterez GeneID 8626
General Information The p63 gene is a homologue of the p53 tumor suppressor gene. Like p53, p63 contains a transactivation (TA) domain induce the transcription of target genes, a DNA binding domain, and an oligomerization domain (OD), used to form tetramers. In contrast to p53, the p63 gene encodes for at least six major isotypes. Three isotypes (TAp63a, TAp63ß, and TAp63¿) contain the transactivating (TA) domain and are able to transactivate p53 report genes and induce apoptosis. In contrast, the other three isotypes (¿Np63a, ¿Np63ß, ¿Np63¿) are transcribed from an internal promoter localized within intron3, lack the TA domain, and act as dominant-negatives to suppress transactivation by both p53 and TAp63 isotypes. p63 is highly expressed in the basal cells of the epithelium significant for proper limb outgrowth and morphogenesis.4 In differentiating tissues, p63 is crucial for maintaining the stem cell identity of the basal cells, and is indispensable for correct development of the skin as well as the limb. p63-deficient mice lack all squamous epithelia and their derivatives, including hair, whiskers, teeth, as well as mammary, lacrimal, and salivary glands.Tissue specificity
Immunogen Synthesized peptide of human p63a. ;
Clone MM4E5;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Leukemia. 2008 Sep;22(9)
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