Mouse Monoclonal Antibody to SNAI1

Item#:

sAP-0497

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0497
Product Name	Mouse Monoclonal Antibody to SNAI1
Target Molecle	SNAI1
Aliases	SNA; SNAH; SLUGH2; dJ710H13.1; SNAI1
Species	Human
MW	29kDa
Enterez GeneID	6615
General Information	Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity
Immunogen	Purified recombinant fragment of human SNAI1 expressed in E. Coli.
Clone	MM6D2;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47)