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Mouse Monoclonal Antibody to NACC1
Item#:
sAP-0489
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0489
Product Name Mouse Monoclonal Antibody to NACC1
Target Molecle NACC1
Aliases NAC1; BEND8; NAC-1; BTBD14B; FLJ37383; NACC1
Species Human
MW 58kDa
Enterez GeneID 112939
General Information NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors . NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system . NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene . The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway . NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 . Tissue specificity
Immunogen Purified recombinant fragment of human NACC1 expressed in E. Coli.
Clone MM6H2;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Am J Hypertens. 2009 Nov;22(11)
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