Mouse Monoclonal Antibody to KDM3A

Item#:

sAP-0486

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0486
Product Name	Mouse Monoclonal Antibody to KDM3A
Target Molecle	KDM3A
Aliases	TSGA; JMJD1; JHDM2A; JHMD2A; JMJD1A; KIAA0742; DKFZp686A24246; DKFZp686P07111; KDM3A
Species	Human;
MW	147kDa
Enterez GeneID	55818
General Information	This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and alpha-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.
Immunogen	Purified recombinant fragment of human KDM3A expressed in E. Coli.
Clone	MM2E1;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. DNA Res. 1998 Oct 30;5(5)