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Mouse Monoclonal Antibody to CDH1
Item#:
sAP-0479
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0479
Product Name Mouse Monoclonal Antibody to CDH1
Target Molecle CDH1
Aliases UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1
Species Human; Mouse; Monkey
MW 135kDa
Enterez GeneID 999
General Information E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity
Immunogen Purified recombinant fragment of human CDH1 expressed in E. Coli.
Clone MM7A2;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide. ;
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. Ann Oncol. 2006 Jun;17 Suppl 7
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