Mouse Monoclonal Antibody to STAT3

Item#:

sAP-0474

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0474
Product Name	Mouse Monoclonal Antibody to STAT3
Target Molecle	STAT3
Aliases	APRF; HIES; FLJ20882; MGC16063; STAT3
Species	Human; Mouse; Monkey
MW	88kDa
Enterez GeneID	6774
General Information	The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development . Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3a (86 kDa) and Stat3ß (79 kDa) depend on cell type, ligand exposure or cell maturation stage. It is notable that Stat3ß lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.Tissue specificity
Immunogen	Purified recombinant fragment of human STAT3 expressed in E. Coli.
Clone	MM3B5;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Nat Genet. 2009 Dec;41(12)