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Mouse Monoclonal Antibody to CD276
Item#:
sAP-0455
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0455
Product Name Mouse Monoclonal Antibody to CD276
Target Molecle CD276
Aliases B7H3; B7-H3; 4Ig-B7-H3; CD276
Species Human
MW 57kDa
Enterez GeneID 80381
General Information Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558). May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Immunogen Purified recombinant fragment of human CD276 expressed in E. Coli.
Clone MM6A1;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide. ;
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. J Hum Genet. 2009 Jun;54(6)
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