Mouse Monoclonal Antibody to RICTOR

Item#:

sAP-0443

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0443
Product Name	Mouse Monoclonal Antibody to RICTOR
Target Molecle	RICTOR
Aliases	PIA; mAVO3; KIAA1999; MGC39830; DKFZp686B11164; RICTOR
Species	Human; Monkey; Mouse
MW	192kDa
Enterez GeneID	253260
General Information	Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals . mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GßL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GßL, Sin1 and rictor . The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro . This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes . This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR .
Immunogen	Purified recombinant fragment of human RICTOR expressed in E. Coli.
Clone	MM7B3;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1. Cell. 2005 Sep 23;122(6)