Mouse Monoclonal Antibody to KLHL13

Item#:

sAP-0420

Size	Price	Quantity
50.0 ug	$320.00

Catalog Number	sAP-0420
Product Name	Mouse Monoclonal Antibody to KLHL13
Target Molecle	KLHL13
Aliases	BKLHD2; FLJ10262; MGC74791; KLHL13
Species	Human
MW	74kDa
Enterez GeneID	90293
General Information	KLHL13 (kelch-like 13), also known as BKLHD2 (BTB and kelch domain-containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate- specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase.
Immunogen	Purified recombinant fragment of human KLHL13 expressed in E. Coli. ;
Clone	MM8D1;
Isotype	Mouse IgG1
Size and Concentration	100µg/1mg/ml
Supplied As	Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide. ;
Reconstitution and Storage	Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications	ELISA
References	1.Invest Ophthalmol Vis Sci. 2009 Jun;50(6)