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Mouse Monoclonal Antibody to PAX6
Item#:
sAP-0419
Size Price Quantity
50.0 ug $320.00
Catalog Number sAP-0419
Product Name Mouse Monoclonal Antibody to PAX6
Target Molecle PAX6
Aliases AN; AN2; MGDA; WAGR; D11S812E; MGC17209; PAX6
Species Human
MW 46kDa
Enterez GeneID 5080
General Information Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells .PAX6 is the most researched of the PAX genes and appears throughout the literature as a "master control" gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues. This transcription factor is most famous for its use in the interspecifically induced expression of ectopic eyes and is of medical importance because heterozygous mutants produce a wide spectrum of ocular defects such as Aniridia in humans. This gene encodes paired box gene 6, one of many human homologues of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause aniridia as well as Peter's anomaly, both ocular diseases.
Immunogen Purified recombinant fragment of human PAX6 expressed in E. Coli. ;
Clone MM1C8;
Isotype Mouse IgG1
Size and Concentration 100µg/1mg/ml
Supplied As Lyophilized Powder from 100µl of Ascitic fluid containing 0.03% sodium azide. ;
Reconstitution and Storage Reconstitued with 100µl sterile DI H2O, at stored at 4°C or -20°C for short or long term storage.
Applications ELISA
References 1. BMC Med Genet. 2007 Sep 19;8 Suppl 1
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